منابع مشابه
Anti-tumor effects of genetic vaccines against HPV major oncogenes
Expression of HPV E5, E6 and E7 oncogenes are likely to overcome the regulation of cell proliferation and to escape immunological control, allowing uncontrolled growth and providing the potential for malignant transformation. Thus, their three oncogenic products may represent ideal target antigens for immunotherapeutic strategies. In previous attempts, we demonstrated that genetic vaccines agai...
متن کاملHPV vaccines: a controversial issue?
Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the pro...
متن کاملProphylactic HPV vaccines.
The HPV L1 VLP vaccines are immensely important developments in public health and the benefits that they promise are immense, offering the opportunity to prevent, in the long term, 80% of cervical cancers, 60% of vulval cancers and 80% of anal cancers in women. In the short to medium term they will prevent at least 90% of genital warts and have a major impact on the incidence of high grade CIN,...
متن کاملImmunobiology of HPV and HPV vaccines.
Genital human papillomavirus (HPV) infection with both low- and high-risk types is common, but most infections resolve as a result of a cell-mediated immune response. Failure to induce an effective immune response is related to inefficient activation of innate immunity and ineffective priming of the adaptive immune response; this defective immune response facilitates viral persistence, a key fe...
متن کاملProphylactic HPV Vaccines
Cervical cancer and its precursor intra-epithelial lesions are linked to infection by a subset of human papillomavirus (HPV) types, the so-called “high-risk” HPVs, the most prevalent being HPV16 and HPV18. Two prophylactic vaccines containing combinations of the major capsid protein (L1) of HPV16 and HPV18 have been shown to efficiently prevent infection by inducing capsid-specific neutralizing...
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ژورنال
عنوان ژورنال: Prescriber
سال: 2006
ISSN: 0959-6682,1931-2253
DOI: 10.1002/psb.454